Cardiac myosin activators: up and coming

Towards improved outcome after cardiac arrest: new studies coming up

Patients admitted to an intensive care unit after cardiac arrest often suffer from severe brain injury. This injury worsens further after restoration of circulation due to the cascade of reactions in the brain. Neuroprotective therapies aim to diminish this secondary brain injury, thereby targeting at a better outcome. Several new large international studies will start soon, next to two smaller...

Fluorescence spectra of cardiac myosin and in vivo experiment: studies on daunorubicin-induced cardiotoxicity

Objective(s):The objective of this study was to investigate the interaction of daunorubicin (DNR) and cardiac myosin (CM) and the changes in mice hearts to exhibit DNR-induced cardiotoxicity . Materials and Methods:The interaction between DNR and CM was expressed using fluorescence quenching at pH 4.0-9.0 and 15-37 °C. DNR-induced cardiotoxicity was studied using in vivo experiment.  Forty grou...

What’s Coming Up..................................... 20 Correction

CCR5 inhibitors: up and coming new agents.

A new class of antiretroviral drugs came on the scene in 2003 with the approval of the first entry inhibitor, enfuvirtide (T-20, Fuzeon). Considerable research has been directed toward discovery of additional drugs that target the cell-entry stage of HIV replication, and CCR5 inhibitors--agents that block viral entry via a novel mechanism of action--are poised to join the antiretroviral armamen...

Measuring the MBTI . . . And Coming Up Short

Imagine a test that would allow you to predict the type of career for which a person is best suited For example, Mary comes to you for career counseling. She presents you with her education and work history, and an outline of her career objectives. Specifically, she says that she would like to find an entry-level position where she can help people, and is interested in a career in the social se...